Sedusa (voiced by Jennifer Hale) is a young, beautiful mistress of disguise and seductress who uses her feminine wiles to influence men to do her bidding. When her identity is revealed, she typically doffs down to her leotard battle suit and fights with her whip-like hair (which she can control). Femme Fatale referred to her as "That chick in the underwear." In her introduction episode ("Mommy Fearest"), she poses as an ordinary woman named "Ima Goodlady". She tries to manipulate the Professor against the girls, but is unsuccessful. She becomes powerless when her hair becomes wet (or cut off). In one episode, she had the ability to whip off globs of sticky hair gel adhering people to walls. In the episode "Aspirations", Sedusa seduces the Gangrene Gang into stealing several Egyptian artifacts. She is still bald from when Miss Bellum cuts off her hair. When she gets the artifacts, she becomes giant and rather than hair, deadly asps grow from her head. Sedusa betrays the Gangrene Gang, which leads to Ace telling Blossom to take the crown from Sedusa. Sedusa loses her hair once more, as well as her gigantic stature. She begs the boys to help her, but they refuse and Sedusa is sent back to jail. Her eyes change color. When she is "happy" or "nice" her eye color is green, but when she is angry or evil, they are red. This is seen in the episode "Mommy Fearest". She is based on Medusa from Greek mythology.
In Powerpuff Girls Z, Sedusa was originally Annie, a quiet and sweet girl, friend of the Powerpuff Girls, who got struck by a black Chemical Z ray while she was trying on Miss Bellum's lipstick and turned into Sedusa. As with Princess Morbucks, the effects of the black rays are not permanent in Annie and she can revert back to her normal self, however, the curse causes her to transform into Sedusa whenever she wears lipstick while anxious. As Sedusa, Annie can wear makeup to make herself look like anyone, as well as use her hair like tentacles, traits shared with her American counterpart, but unlike her American counterpart, Annie (as well as Sedusa) is in love with Jason, a regular client of her shop, rather than Professor Utonium.Possibly she have a playful affection to poochie because in his debut she defeats him in a little fight at style bull corrida